Abstract: Aiming at the problem of incomplete research methods and comparison factors of current medium-voltage distribution network wiring modes, a comprehensive comparison of different networking schemes for typical wiring is proposed. Based on various typical connections of the current distribution network, the ideal area is constructed based on the actual parameters of the Dongguan power grid for networking research, the fault traversal method is used to calculate the reliability index due to the fault, the line loss based on the load density distribution is improved, and the PSD-SCCP short circuit calculation program analyzes the short circuit level of the open/closed loop mode of the ring network connection, and comprehensively compares the application of each network plan based on the economic indicators analyzed by the net present value method and the adaptability of each network connection. Using the actual mixed-line ring network group in Dongguan, the comparison and calculation of the model in the initial stage of power grid construction and the urbanization process are simulated, and the comparison results verify the feasibility of the comprehensive comparison of typical wiring methods. The comprehensive comparison of networking schemes based on typical wiring methods has certain enlightenment and practical guidance for regional distribution network planners.