Abstract: The common-mode electromagnetic interference(EMI) generated by the switching process of pulse width modulation (PWM) inverters has a significant negative impact on the system. The new series-end winding inverter topology is used as the research object, and the variable switching frequency pulse width modulation(VSFPWM) technique based on the current ripple prediction model is adopted to realize the accurate control of current ripple and accomplish the spreading suppression of common-mode EMI and the reduction of switching loss while considering the effect of inductor saturation in the actual inverter system. The model predictive VSFPWM strategy considering inductor saturation in series-end winding topology is proposed, and the performance of EMI suppression effect, output current quality and switching loss under different VSFPWM strategies are compared and analyzed by simulation and experiment, which verify that the proposed strategy can effectively suppress common-mode EMI, reduce switching losses, and ensure satisfying output current waveforms.