Abstract: With guaranteeing the motor output performance, by optimizing the motor stator structure, the modal frequency arousing the main vibration and noise of the motor is adjusted to avoid resonances, thereby reducing the vibration and noise of the permanent magnet synchronous motor. First, experiment and simulation are conducted to analyze the vibration and noise of the motor, based on which the main order of the electromagnetic force causing electromagnetic noise is determined. Next, taking the stator structural parameters of the motor as variables, the high-sensitivity optimization variables are selected through sensitivity analysis and the response surface model of the selected optimization variables is developed. Afterwards, based on the developed response surface model, the parameters of the variables are optimized by the genetic algorithm to obtain the optimal structure parameters of the stator. Finally, the output performances of the motor before and after optimization are calculated and analyzed by the finite element method, the correctness of the optimization method is verified by the simulation of the electromagnetic vibration and noise of the motor. After optimization, the output performance of the motor is obviously improved and the vibration and noise of the motor are effectively suppressed.