Abstract: University laboratories are important places for scientific research,technological innovation and talent cultivation.Laboratory safety management is a prerequisite for ensuring the orderly operation of laboratories. In view of the problems in the safety management of materials laboratories,combined with the characteristics of disciplines and majors,the safety management measures of laboratories are explored from the aspects of management mechanisms,education and training,safety inspections,hazard source control,and reward and punishment systems. Laboratory safety management system is constructed to provide ideas and references for the safety management of base laboratories in universities.