Abstract: Inductively coupled plasma mass spectrometry(ICP-MS) is recognized as the most powerful trace and ultra-trace inorganic element and isotope analysis technology. It is widely used in the field of forensic science due to its high sensitivity, low detection limit, wide linear dynamic range, simultaneous analysis of multiple elements, and simple sample treatment. This paper reviews the application progress of ICP-MS in the field of forensic science in recent years,such as biological samples, food, medicine and shooting residues. The pretreatment methods of heavy metal elements and other elements in biological samples, food and medicine are introduced, and the development trend of ICP-MS in this field is prospected. This paper will provide an effective reference value for the research and application of ICP-MS in toxicant analysis in the field of forensic science and the research and application of heavy metal elements and other elements in the material evidence related to trace evidence cases.This paper will provide an effective reference value for the analysis of heavy metal elements and other elements in forensic evidence by ICP-MS.