Abstract: In the past seventy years since the sale of the first mainframe computer by IBM in 1953, the world have become an information society that relies on networked computing systems in all aspects of work and life. Along with the evolution of computing, Information Systems have become an indispensable discipline in business and management that serves the needs of other managerial disciplines and performs its  business functions. Further information technology (IT) has become a sine qua non for the survival of a business and a source of much competitive advantage. Without advanced IT systems, an organization cannot survive for long today. In this paper, we recount and evaluate the evolution of Information Systems research since its infancy in the 1980s by empirically analyzing the research that has been published in leading academic journals. We found that research in Information Systems has evolved through several stages. During this evolution the basic disciplines from which researchers have drawn have also shifted considerably. Over this period the underlying technology support for the research has also developed enormously from simple data processing to systems development, client-server networks, electronic commerce, several generations of the Web (1.0, 2.0 and 3.0) and blockchain. Each new technology generation has spawned its own unique set of research issues and in turn influenced the research agenda of the scholars in the IS field in terms of research topics, methods, and theories. History offers a mirror to the past and a lesson for the present, and thus we believe that the results of this study should provide instructional value for new researchers such as doctoral students in Information Systems and other related disciplines.